Study Finds Men with Hemophilia Have Higher Rates of Depression, Anxiety, and Obesity than the General U.S. Male Population

Hemophilia is a rare, inherited bleeding disorder in which the blood does not clot properly. Blood contains many proteins called clotting factors that can help stop bleeding. People with hemophilia have low levels of either factor VIII (8) or factor IX (9) blood clotting proteins. Hemophilia A is caused by low levels of factor VIII, and hemophilia B is caused by low levels of factor IX. Hemophilia can lead to excessive bleeding after an injury or trauma, as well as bleeding that can occur for no apparent reason.

Medical advancements have helped people with hemophilia live longer, but longer life can lead to other health problems that can develop with age, such as high blood pressure and obesity. These health problems can have serious consequences on one’s overall health and well-being, and they can be challenging to treat in a person with a bleeding disorder. As more people with hemophilia are living longer, it’s important to know what other health problems are affecting the aging hemophilia community to better understand the healthcare needs of this population.

About the Study

Community Counts is a public health tracking system that monitors the care and health outcomes of patients with bleeding disorders receiving care at federally funded hemophilia treatment centers (HTCs) across the United States.

Prevalence is a statistical concept referring to the number of people (existing cases) who have a disease or medical condition at a particular time.

Researchers from the Centers for Disease Control and Prevention (CDC) and the U.S. HTC Network analyzed information from Community Counts on men age 45 years and older who were receiving care for hemophilia at HTCs from December 2013 to March 2021. The study aimed to

Since the study examined age-related health conditions, researchers divided the men with hemophilia into two groups—middle-aged (age 45 to 64 years) and older (age 65 years or more)—for comparison.

To compare the group with hemophilia with the general U.S. population, researchers used similar information collected in the CDC’s National Health Interview Survey.

Read the full scientific article.

Main Findings

Overview of the Study Sample

Comparison with the General U.S. Male Population

Differences in Health Conditions by Severity Level

Gaps and Future Directions


Future Directions

As people living with hemophilia are now living longer, it’s important to understand why they experience higher rates of certain health problems, such as depression, anxiety, and obesity. Understanding how these health problems impact overall health and well-being will allow researchers to better address the healthcare needs of the aging hemophilia community.

Paper Reference

Soucie JM, Le B, Dupervil B, Poston JN. Prevalence of comorbid conditions among older males with haemophilia receiving care in haemophilia treatment centers in the United States. Haemophilia. 2022;28:986–995.

Source: Centers for Disease Control and Prevention, July 2023

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